2. Signaling Pathways
  3. Epigenetics
  4. RNA MTase

RNA MTase

RNA Methyltransferase; METTL

RNA Methyltransferase catalyzes the RNA methylation modifications, including N6-methyladenosine (m6A) modification of mRNA, 5-methylcytosine (m5C) modification of RNA, N1-methyladenosine (m1A) modification of RNA, pseudouridine modification of RNA, N7-methylguanosine (m7G) modification of RNA, and 2'-O-methyluridine (Um) modification of RNA. RNA Methyltransferase regulates the gene expression, affects the expression of immune checkpoint proteins, and participates in the cell proliferation and differentiation. RNA Methyltransferasecan be divided into two groups: m6A methyltransferases such as METTL3/14, WTAP, VIRMA/KIAA1429, and the other methyltransferases such as NSun2, PCIF1, METTL16, etc. RNA Methyltransferasedysfunction could lead to tumor development, drug resistance, immune escape, or other metabolic and neurological diseases[1][2].

RNA MTase Related Products (6):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-158301
    MY-1B
    		Inhibitor 99.94%
    MY-1B is a covalent inhibitor of the RNA Methyltransferase NSUN2 (IC50: 1.3 μM). MY-1B stereoselectively ligands active-site cysteine residues (C271) of NSUN2. MY-1B can stereoselectively and covalently bind to PSME1, disrupting the proteasome regulatory complex and downregulating the presentation of specific MHC-I subtypes.
    MY-1B
  • HY-178159
    SA91-0178
    		Inhibitor 98.14%
    SA91-0178 is a METTL1 inhibitor. SA91-0178 inhibits m7G methylation of RNA, reduces SARM1 stability, mitigates NAD+ depletion and metabolic reprogramming in macrophages. SA91-0178 demonstrates excellent protective efficacy against multiple organ injury in cecal ligation and puncture (CLP)-induced and ischemia/reperfusion (I/R)-induced mice. SA91-0178 can be used for the study of systemic inflammatory diseases.
    SA91-0178
  • HY-153141
    MP-1
    		Ligand
    MP-1 is a potent Fumarate hydratase-dependent hit. MP-1 engages an array of functional cysteines, including one lying in the Zn-finger domain of the tRNA methyltransferase enzyme TRMT1. MP-1 causes fumarate hydratase-dependent synthetic lethality in a metastatic hereditary leiomyomatosis and renal cell carcinoma cell line.
    MP-1
  • HY-181962
    ZINC-1000507789
    		Inhibitor
    ZINC-1000507789 is a non-covalent and reversible RNA cytosine-5 methyltransferase NSUN2 inhibitor. ZINC-1000507789 is applicable to the research of NSUN2-driven malignancies.
    ZINC-1000507789
  • HY-180544
    TrmD-IN-1
    		Inhibitor
    TrmD-IN-1 (compound 8h) is a selective Staphylococcus aureus tRNA m1 G37 methyltransferase (TrmD) inhibitor with a KD of 2.48 μM and an IC50 of 1.16 μM. TrmD-IN-1 exhibits selectivity over E. coli (KD > 30 μM) and H. influenzae TrmD (KD > 30 μM) and Trm5 (IC50 > 30 μM).
    TrmD-IN-1
  • HY-175228
    RNA MTase-IN-1
    		Inhibitor
    RNA MTase-IN-1 (Compound 47) is a RNA methyltransferase (RNA MTase) inhibitor with an IC50 of 68  μM for 16S rRNA (m1A1408) methyltransferase (NpmA). RNA MTase-IN-1 has a significant inhibitory activity against pathogen-associated aminoglycoside-resistance. RNA MTase-IN-1 can be used for resistant bacterial infections research.
    RNA MTase-IN-1