RNA MTase
RNA Methyltransferase; METTL
RNA Methyltransferase catalyzes the RNA methylation modifications, including N6-methyladenosine (m6A) modification of mRNA, 5-methylcytosine (m5C) modification of RNA, N1-methyladenosine (m1A) modification of RNA, pseudouridine modification of RNA, N7-methylguanosine (m7G) modification of RNA, and 2'-O-methyluridine (Um) modification of RNA. RNA Methyltransferase regulates the gene expression, affects the expression of immune checkpoint proteins, and participates in the cell proliferation and differentiation. RNA Methyltransferasecan be divided into two groups: m6A methyltransferases such as METTL3/14, WTAP, VIRMA/KIAA1429, and the other methyltransferases such as NSun2, PCIF1, METTL16, etc. RNA Methyltransferasedysfunction could lead to tumor development, drug resistance, immune escape, or other metabolic and neurological diseases[1][2].
Verweise:
- [1]. Zhao Y, et al., ALYREF (Aly/REF export factor): A potential biomarker for predicting cancer occurrence and therapeutic efficacy. Life Sci. 2024 Feb 1;338:122372. [Content Brief]
- [2]. Luo P, et al., N6-methyladenosine RNA modification in PD-1/PD-L1: Novel implications for immunotherapy. Biochim Biophys Acta Rev Cancer. 2023 May;1878(3):188873. [Content Brief]
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RNA MTase Verwandte Produkte (8)
Verwandte Produkte (8)
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MY-1B
0 ImagesMY-1B is a covalent inhibitor of the RNA Methyltransferase NSUN2 (IC50: 1.3 μM). MY-1B stereoselectively ligands active-site cysteine residues (C271) of NSUN2. MY-1B can stereoselectively and covalently bind to PSME1, disrupting the proteasome regulatory complex and downregulating the presentation of specific MHC-I subtypes.
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SA91-0178
0 ImagesSA91-0178 is a METTL1 inhibitor. SA91-0178 inhibits m7G methylation of RNA, reduces SARM1 stability, mitigates NAD+ depletion and metabolic reprogramming in macrophages. SA91-0178 demonstrates excellent protective efficacy against multiple organ injury in cecal ligation and puncture (CLP)-induced and ischemia/reperfusion (I/R)-induced mice. SA91-0178 can be used for the study of systemic inflammatory diseases.
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RNMT-IN-1
0 ImagesArt. -Nr.: HY-186197CAS. Nr.: 1381321-59-0RNMT-IN-1 is a RNMT inhibitor with a pIC50 of 5.5. RNMT-IN-1 can be used for research on various cancers.
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MP-1
0 ImagesArt. -Nr.: HY-153141CAS. Nr.: 2035018-15-4MP-1 is a potent Fumarate hydratase-dependent hit. MP-1 engages an array of functional cysteines, including one lying in the Zn-finger domain of the tRNA methyltransferase enzyme TRMT1. MP-1 causes fumarate hydratase-dependent synthetic lethality in a metastatic hereditary leiomyomatosis and renal cell carcinoma cell line.
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Antibacterial agent 355
0 ImagesArt. -Nr.: HY-184445Antibacterial agent 355 is a bacterial tRNA (m1G37) methyltransferase (TrmD) inhibitor with an IC50 of 0.85 μM against E. coli. Antibacterial agent 355 shows weak inhibitory activity against human Trm5, with an approximate IC50 of 1.88 mM. Antibacterial agent 355 inhibits the growth of bacterial strains expressing TrmD. Antibacterial agent 355 can be used for the research of bacterial infections.
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TrmD-IN-1
0 ImagesArt. -Nr.: HY-180544TrmD-IN-1 (compound 8h) is a selective Staphylococcus aureus tRNA m1 G37 methyltransferase (TrmD) inhibitor with a KD of 2.48 μM and an IC50 of 1.16 μM. TrmD-IN-1 exhibits selectivity over E. coli (KD > 30 μM) and H. influenzae TrmD (KD > 30 μM) and Trm5 (IC50 > 30 μM).
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RNA MTase-IN-1
0 ImagesArt. -Nr.: HY-175228RNA MTase-IN-1 (Compound 47) is a RNA methyltransferase (RNA MTase) inhibitor with an IC50 of 68 μM for 16S rRNA (m1A1408) methyltransferase (NpmA). RNA MTase-IN-1 has a significant inhibitory activity against pathogen-associated aminoglycoside-resistance. RNA MTase-IN-1 can be used for resistant bacterial infections research.
